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Jan Bussink - full professorJan Bussink is a Radiation Oncologist and the head of the Laboratory for Experimental Radiotherapy and Principal Investigator for several research projects investigating tumor microenvironmental properties involved in radioresistance such as for instance tumor cell hypoxia with radiotherapy. He is involved in several international collaborations.
The lab is committed to investigate resistance to radiotherapy in which hypoxia is involved. The research has a strong translational character and is directed towards Head and Neck Cancer, Non Small Cell Lung Cancer and breast cancer.
Current topics are focused on: analyzing EGFR signaling related to radiation resistance (PI3-K/AKT pathway related to tumor vasculature, proliferation and hypoxia involvement)non-invasive imaging of the tumor microenvironment (vasculature, hypoxia, proliferation and the EGFR) and assessment of endogenous markers related to tumor cell metabolism (lactate, monocarboxylate transporters etc).
Personal prizes & awards national & international